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Being overweight is defined by a body mass index (BMI) of 25 to 29.9, while obesity means you have a BMI of 30 or higher

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This means: No human PK reference data No human bioavailability data No human metabolism or clearance data Rodent-to-human PK extrapolation is therefore speculative This is a major context for research framing

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Hydrochlorothiazide may be used to reduce hypercalciuria and prevent the recurrence of calcium-containing renal calculi

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